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The aggregation of lipoylated proteins, loss of Fe-S cluster proteins, and reversibility by copper chelation should remain the fundamental criteria for establishing cuproptosis in lung cancer models, and should not be replaced by nonspecific findings such as increased ROS, GSH depletion, or mitochondrial injury

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[DOI] [PMC free article] [PubMed] [Google Scholar] 285.Ke M., Chong C.-M., Zhu Q., Zhang K., Cai C.-Z., Lu J.-H., Qin D., Su H